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Based on results from the guanosine 5′-O-(3-[ 35 S]thio)triphosphate ([ 35 S]GTP γ S) stimulation assay, mitragynine was reported to be a competitive antagonist at μ -opioid receptors (Obeng et al., 2021), suggesting that other alkaloids may contribute to the opioid-like effects
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doi: 10.1016/j.cellimm.2013.09.007 110 WeyandCMGoronzyJJ
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