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the method comprises administering to the subject a composition comprising a myostatin inhibitor, e.g., an antibody or antigen-binding fragment thereof that binds specifically to pro/latent myostatin as disclosed herein (e.g., Ab102, Ab109, Ab130, Ab132, Ab133, or Ab141 ), in an amount effective to preferentially increase type II or fast twitch fibers over type I or slow twitch fibers fiber type switch, thereby preferentially increasing type II or fast twitch fibers over type I or slow twitch fibers in the subject

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Van Cauter and colleagues, JAMA , 2000, documented that slow wave sleep falls from about 18.9 percent of the night in early adulthood to roughly 3.4 percent by midlife, with growth hormone secretion declining in lockstep