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glutathion peroxydase élevée GPX1 (Glutathione Peroxidase, GSHPx) Gene Variants and Cardiovascular Reduced glutathione is involved
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Conditions such as pernicious anemia, gastrointestinal disorders, or surgical procedures that affect the digestive system can impede B12 absorption, necessitating supplemental injections
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R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)
Reduced glutathione is involved in the synthesis and repair of DNA
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