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Sensitivity analyses for primary outcomes were pre-defined in the study protocol and included: (1) imputing missing values of dropped cases, (2) deleting cases who were non-adherent, (3) statistically adjusting for perceived stress and years of hot flushes (potential confounders) 11 , and (4) excluding patients who made lifestyle changes
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LCS-7, a peptide mycotoxin derived from leucinostatin (LCS)-A, binds to the crucial carboxylate group of Glu59 on the mitochondrial ATP synthase subunit c, effectively inhibiting ATP synthase activity
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