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The intestine facilitates material exchange with luminal contents through specialized pathways—notably the paracellular pathway, which typically permits the passage of molecules larger than 15 Å (approximately 3.5 kDa) ( 4 Alterations in the structural and functional characteristics of the GM The GM is intricately linked to health in the aged, as it may influence age-related alterations in innate immunity, sarcopenia, bone metabolism, and cognitive function—all of which contribute to frailty in older persons
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Nguyen et al., 2019
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