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The inflammation-modulatory effects of hBMSC treatment included a significant increase in the gene expression of IL-10 and its receptor in ovarian tissues, elevated serum levels of IL-10, IFN-γ, and tissue inhibitor of metalloproteinase-2, and a decrease in the gene expression of pro-inflammatory markers such as IL-6, IL-1β, CCL2, and CD11c in the adipose tissue of PCOS mice [135]
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