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The materials reviewed did not provide sufficient primary citations to evaluate those specific mechanism and comparison claims, so this article does not reproduce them
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JBSNF-000088 binds to the active site on NNMT and leads to the demethylation of SAM to SAH ( JBSNF-000028 (Ruf et al., 2022) and JBSNF-000088 ( JBSNF-000265 was discovered through Structure-Activity Relationship (SAR) studies (Ruf et al., 2018) as a compound that binds to NNMT in a manner similar to that of NAM
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