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Inappropriate lifestyle, such as high intake of coffee (31), alcohol, obesity and smoking can also lead to HHcy (32), which may be related to vitamin malabsorption
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We confirmed these findings using another orthotopic patient derived mesenchymal transcriptional subtype and treatment resistant HF2303 GBM tumor model where similar methionine related metabolites involved in transmethylation, antioxidant synthesis and polyamine synthesis exhibited a comparable trend of elevated levels in GBM compared to contralateral brain (Fig
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