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32 The Wnt signaling network can be separated into the β-catenin-dependent Wnt signaling pathway and the β-catenin-independent Wnt signaling pathway.2 The primary activators of the former canonical pathway are Wnt2b, Wnt3, Wnt3a, Wnt8a, Wnt8b, Wnt9a, and Wnt10b
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The expression of other effector genes, such as PRF and GZMB, have been shown to be significantly upregulated as a result of hypomethylation in the promoter regions of these genes in effector CD8+ T cells (90)
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