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gst glutathione kd Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Transferase also known as
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JNK Depletion of GSH by NAPQI results in increased H 2 O 2 release from mitochondria to cytoplasm, which could oxidize thioredoxin and cause thioredoxin to disassociate from apoptosis signaling-regulating kinase 1 (ASK-1) [41]
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In the cardiovascular system, succinate released by macrophages stimulated the production of inflammatory cytokine IL-1β by activating HIF-1α, thus inducing endothelial inflammation and then promoting atherosclerosis
Transferase also known as GST
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