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The conditioned medium from pancreatic cancer cells contained high IGFBP3 and caused significant myofiber wasting, which was prevented by IGFBP3 knockdown or neutralizing antibody [105]
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Other ongoing phase II clinical trials are investigating the effect of the PD-L1 inhibitor durvalumab in combination with pazopanib or tremelimumab (CTLA-4 inhibitor) to treat advanced STS (NCT03798106 and NCT02815995)
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